MSc Applied Statistics and Infometrics at IIT Bombay can be challenging for some students who did their B.Sc from Mumbai University, especially if they did not receive sufficient training in statistics. In comparison to Delhi University and Calcutta University, the Mumbai University curriculum is relatively deficient in statistical topics. Consequently, most of the students in the class come from DU and CU. While DU and CU students are often comfortable during the first quarter or half of the semester since they studied similar topics in their bachelor's programs, Mumbai University students may struggle to keep up.

Despite the challenges, this course is in line with current analytics trends in the market. The course requires students to complete not only statistics courses but also intermediate-level computer science courses such as C, C++, Data Structures, and Applied Algorithms. Students also receive some exposure to statistical software, depending on which software the professor prefers: SaS or R.