Doctor of Philosophy [Ph.D] (KESS2 PhD in Biosciences: Delineating how oncogenic PI3K/PTEN signalling contributes to prostate cancer)
3 years
Full Time
Field of Study:
- Despite high response rates to androgen deprivation therapy (ADT) in advanced PCa patients, nearly all eventually develop progressive, castrate-resistant prostate cancer (CRPC). The mainstay of treatment for lethal CRPC is chemotherapy/ADT, yet survival is poor, emphasising the urgent clinical need to identify novel therapeutic strategies to treat PCa/CRPC.
- Owing to the high frequency of oncogenic PI3K signalling in PCa/CRPC and its link to ADT resistance, this pathway is an attractive therapeutic target. Indeed loss of PTEN, a negative regulator of the PI3K pathway, occurs in 50-70% of PCa patients and is an inherent property of CRPC in mice.
- Nevertheless, how the PI3K pathway contributes to PCa growth and CRPC transition is not clear. Dr. Pearson has recently discovered that hyperactivation of the PI3K catalytic subunit p110a (encoded by PIK3CA) causes rapid de novo castration resistance in combination with Pten loss, yet single mutants acquire CRPC over time.
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Important Dates
University allocates places on a first-come, first-served basis, so students are recommended to apply as early as possible.
Scholarship Grants & Financial Aids
| Name | Scholarship Per Student | Level of Study | Type | |
|---|---|---|---|---|
| Commonwealth Rutherford Fellowship | Scholarship per student£ 3,105/Yr$3,105 | Level Of StudyDoctorate | TypeMerit-Based | |
| Monica Cole Research Grant | Scholarship per student£ 1,291/Yr$1,291 | Level Of StudyApprenticeship | TypeMerit-Based | |
| Commonwealth Professional Fellowship | Scholarship per studentVariable Amount | Level Of StudyDoctorate | TypeMerit-Based | |
| JN Tata Endowment Scholarship | Scholarship per studentVariable Amount | Level Of StudyDoctorate | TypeMerit-Based | |
| Commonwealth Scholarship | Scholarship per studentVariable Amount | Level Of StudyDoctorate | TypeMerit-Based | |
| Forktip Women’s- Innovation Scholarship | Scholarship per studentVariable Amount | Level Of StudyBachelor | TypeCollege-Specific |
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Important Dates
| Program | Important Dates |
|---|---|
| M.B.A | Accommodation Deadline (31st Jul 2022) Open day 1 (2022-23) (1st Nov 2022) |
| M.Sc Data Science and Analytics | Accommodation Deadline (31st Jul 2022) Open day 1 (2022-23) (1st Nov 2022) |
| L.L.M | Accommodation Deadline (31st Jul 2022) Summer Application Deadline (31st Jul 2022) Open day 1 (2022-23) (1st Nov 2022) |
| M.P.H | Accommodation Deadline (31st Jul 2022) Open day 1 (2022-23) (1st Nov 2022) |
| M.B.A Media | Accommodation Deadline (31st Jul 2022) Open day 1 (2022-23) (1st Nov 2022) |
| M.Sc Business Management | Accommodation Deadline (31st Jul 2022) Open day 1 (2022-23) (1st Nov 2022) |
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