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Doctor of Philosophy [Ph.D] [PhD in Viral Immunology: Characterising the HCMV secretome] From Cardiff University

Cardiff, WalesLocation

UniversitySchool type

Estd1883established year

24245enrollment

Public

8.1/10

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Doctor of Philosophy [Ph.D] (PhD in Viral Immunology: Characterising the HCMV secretome)

4 years

Full Time

Field of Study:

University allocates places on a first-come, first-served basis, so students are recommended to apply as early as possible.

The healthcare costs of caring for affected children are >$4 billion/year in the US alone. Following infection, HCMV persists for life in the face of the strongest immune response produced to any infectious agent. To survive, HCMV dedicates most of its genome (it is the largest human virus) to manipulating the host immune response.
Our studies point to orchestrated modulation of host proteins both within [1], and around (extracellular environment), the infected cell. This study seeks to be the first to provide high-resolution analysis and description of all soluble proteins produced by HCMV-infected cells (the secretome), as a foundation to determine how this affects clinical disease.
It will also inform on the impact of genetically manipulating HCMV, which has been proposed as a vaccine vector for HIV and tuberculosis following cure or protection against these diseases in Rhesus models using RhCMV vectors [2,3].

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